Welcome to the Maniaci Lab
We develop chemical biology approaches to uncover and study new mechanisms involved in Ubiquitin and ubiquitin-like biology
Our Research
The Maniaci Lab focuses on understanding the patterns and underlying mechanisms of protein post-translational modifications. We are situated at MRC-PPU, School of Life Sciences, University of Dundee where we are proud to have created a creative, collaborative and open-minded Research Lab.
Current area of study
The major goal of our research is to discover the fundamental principles of how cells expand the complexity of their proteome as consequences of protein post-translational modifications events. We focus on the "cleave-to-modify" mechanism which involves the processing of Ubiquitin-like-domain containing proteins to enable their further modification as a means to regulate protein biological function. In our research we use a multidisciplinary approach with techniques ranging from biochemistry, cell biology, organic chemistry and proteomics to studies in model organisms to gain mechanistic and functional understanding of protein processing and modification and, consequently, reveal new targets for pharmacological intervention to treat disease.
Our Values
We are committed to establish a supporting environment where lab members can think freely, express themselves openly, and exchange ideas with mutual respect to enable creative thinking and innovation. This commitment will promote an equal, inclusive, and diverse community to drive scientific progress.
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